MK6-83 是一种新的 TRPML1 候选激动剂，具有更高的功效和效力。
| Cas No. | 1062271-24-2 |
| 化学名 | 5-methyl-N-[2-(1-piperidinyl)phenyl]-2-thiophenesulfonamide |
| Canonical SMILES | O=S(NC1=CC=CC=C1N2CCCCC2)(C3=CC=C(C)S3)=O |
| 分子式 | C16H20N2O2S2 |
| 分子量 | 336.5 |
| 溶解度 | DMF: 30 mg/mL,DMSO: 30 mg/mL,DMSO:PBS (pH 7.2) (1:2): 0.33 mg/mL,Ethanol: 5 mg/mL |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | MK6-83 is an activator of the transient receptor potential cation channel, mucolipin subfamily (TRPML1). TRPML1 is mutated in mucolipidosis type IV (MLIV), a hereditary lysosomal storage disorder characterized by severe delays in intellectual and motor development. MK6-83 increases activity of TRPML1 in lysosomes expressing either wild type or F465L-mutated channels (EC50s = 110 and 100 nM, respectively) and in MLIV patient-derived fibroblasts. It is more effective for F465L mutations than F408Δ (EC50 = 1,230 nM). It also improves zinc trafficking out of lysosomes in F408Δ-expressing fibroblast cells. |
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