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MK6-83
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MK6-83图片
CAS NO:1062271-24-2
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
MK6-83 是一种新的 TRPML1 候选激动剂,具有更高的功效和效力。
Cas No.1062271-24-2
化学名5-methyl-N-[2-(1-piperidinyl)phenyl]-2-thiophenesulfonamide
Canonical SMILESO=S(NC1=CC=CC=C1N2CCCCC2)(C3=CC=C(C)S3)=O
分子式C16H20N2O2S2
分子量336.5
溶解度DMF: 30 mg/mL,DMSO: 30 mg/mL,DMSO:PBS (pH 7.2) (1:2): 0.33 mg/mL,Ethanol: 5 mg/mL
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述 MK6-83 is an activator of the transient receptor potential cation channel, mucolipin subfamily (TRPML1). TRPML1 is mutated in mucolipidosis type IV (MLIV), a hereditary lysosomal storage disorder characterized by severe delays in intellectual and motor development. MK6-83 increases activity of TRPML1 in lysosomes expressing either wild type or F465L-mutated channels (EC50s = 110 and 100 nM, respectively) and in MLIV patient-derived fibroblasts. It is more effective for F465L mutations than F408Δ (EC50 = 1,230 nM). It also improves zinc trafficking out of lysosomes in F408Δ-expressing fibroblast cells.