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AUT1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AUT1图片
CAS NO:1311136-84-1
包装与价格:
包装价格(元)
5mg电议
25mg电议

产品介绍
AUT1 是一种重组人 Kv3 通道调节剂。
Cas No.1311136-84-1
化学名(5R)-5-ethyl-3-(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)-2,4-imidazolidinedione
Canonical SMILESO=C1N(C2=CC=C(OC3=CC=C(C)C(OC)=C3)N=C2)C([C@@H](CC)N1)=O
分子式C18H19N3O4
分子量341.367
溶解度DMSO : ≥ 250 mg/mL (732.36 mM)
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

AUT1 (AUT-1) is a novel specific, cell permeant modulator of Kv3 channels with EC50 of 4.7 and 4.9 uM for Kv3.1b and Kv3.2a, respectively; displays approximately 10-fold lower potency for Kv3.3 channels, and does not interact with a wide range of ion channels, receptors, and transporters; increases hKv3.1b and hKv3.2a currents by 1049 ± 198% and 226 ± 39%, respectively, at 30 uM; rescue the fast firing capability of FS interneurons following a reduction in Kv3 channel availability, has the potential to rescue normal function and therapeutic benefit in disorders like schizophrenia or age-related cognitive decline.

Reference:

[1]. Rosato-Siri MD, et al. J Pharmacol Exp Ther. 2015 Sep;354(3):251-60.
[2]. Brown MR, et al. J Neurophysiol. 2016 Jul 1;116(1):106-21.
[3]. Parekh PK, et al. Neuropsychopharmacology. 2018 Jan;43(2):435-444.