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Afloqualone
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Afloqualone图片
CAS NO:56287-74-2
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
100mg电议

产品介绍
Afloqualone是一种GABA_A受体β亚型激动剂。
Cas No.56287-74-2
别名氟喹酮; HQ-495
Canonical SMILESO=C1N(C2=CC=CC=C2C)C(CF)=NC3=C1C=C(N)C=C3
分子式C16H14FN3O
分子量283.3
溶解度DMSO : ≥ 33 mg/mL (116.48 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Afloqualone is a agonist of GABA receptor .Target: GABA Receptorin vitro: Afloqualone is a quinazolinone family GABAergic drug.Afloqualone is an analogue of methaqualone. It has sedative and muscle-relaxant effects, resulting from its agonist activity at the β subtype of the GABAa receptor.in vivo: Afloqualone slightly increased the response during the alarm period in one out of 3 rats at 5, 10, and 20 mg/kg p.o., respectively.

[1]. Yamamura M, et al. Effects of afloqualone, a new centrally acting muscle relaxant, on DRL response and CER in rats (author's transl). Nihon Yakurigaku Zasshi. 1981 Oct;78(4):381-92.