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Apimostinel(NRX-1074)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Apimostinel(NRX-1074)图片
CAS NO:1421866-48-9
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
25mg电议

产品介绍
Apimostinel (NRX-1074) (NRX-1074; AGN-241660) 是一种具有口服活性的 NMDA 受体部分激动剂。
Cas No.1421866-48-9
别名NRX-1074; AGN-241660
Canonical SMILESC[C@@H](O)[C@@H](C(N)=O)NC([C@@]1(CC2=CC=CC=C2)N(C([C@H]3N(C([C@H]([C@H](O)C)N)=O)CCC3)=O)CCC1)=O
分子式C25H37N5O6
分子量503.59
溶解度DMSO: 155 mg/mL (307.79 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Apimostinel is an oral NMDA receptor partial agonist.

Apimostinel (NRX-1074) modulates the NMDA receptor in a similar fashion to GLYX-13, but has a synthetic modification to one of the amino acids, conferring increased potency and oral bioavailability[1].

In preclinical models the two compounds both appear to be highly efficacious across a number of CNS disorders[1].

[1]. Naurex's First Orally Active Molecule, NRX-1074, Demonstrates Statistically Significant Improvement in Depression Scores within 24 Hours in Phase 2 Study for Major Depressive Disorder. January 28, 2015.