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Naspm trihydrochloride
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Naspm trihydrochloride图片
CAS NO:1049731-36-3
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍

化学性质

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt479.91
Cas No.1049731-36-3
FormulaC22H34N4O·3HCl
SolubilitySoluble to 100 mM in sterile water
Chemical NameN-(3-((4-((3-aminopropyl)amino)butyl)amino)propyl)-2-(naphthalen-1-yl)acetamide trihydrochloride
Canonical SMILESO=C(CC1=CC=CC2=CC=CC=C12)NCCCNCCCCNCCCN.Cl.Cl.Cl
运输条件蓝冰运输或根据您的需求运输。
一般建议为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Naspm trihydrochloride is a selective antagonist of Ca2+-permeable α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors. AMPA receptors are glutamate-gated ion channels that play central roles in the mammalian brain, mediating fast excitatory synaptic transmission and underlying several forms of synaptic plasticity. On excitatory neurons in adult animals, two types of AMPA receptors are primarily expressed, namely heteromeric channels composed of GluR1 and GluR2 subunits (GluR1/2 receptors), as well as channels composed of GluR2 and GluR3 subunits (GluR2/3 receptors). Naspm trihydrochloride blocks AMPA receptors lacking the GluR2 subunit, with an IC50 value of 0.3 μM for GluR1 homomers.

References:

1. Nilsen A, England PM. A subtype-selective, use-dependent inhibitor of native AMPA receptors. Journal of the American Chemical Society, 2007, 129(16): 4902-4903.

2. Koike M, Iino M, Ozawa S. Blocking effect of 1-naphthyl acetyl spermine on Ca2+-permeable AMPA receptors in cultured rat hippocampal neurons. Neuroscience Research, 1997, 29(1): 27-36.

试验操作

Cell experiment:[2]

Cell lines

Rat hippocampal neurons

Reaction Conditions

0.01 ~ 10 μM Naspm trihydrochloride

Applications

Naspm trihydrochloride (3 μM) selectively inhibited the strong inward rectification and Ca2+-permeable AMPA receptors expressed in type Ⅱ neurons, but showed no effect on AMPA receptors in type Ⅰ neurons. At -60 mV, Naspm trihydrochloride suppressed AMPA receptors in type Ⅱ neurons, with an IC50 value of 0.33 μM. The blocking effect of Naspm trihydrochloride on the Ca2+-permeable AMPA receptors was dose- and voltage-dependent.

Note

The technical data provided above is for reference only.

References:

1. Nilsen A, England PM. A subtype-selective, use-dependent inhibitor of native AMPA receptors. Journal of the American Chemical Society, 2007, 129(16): 4902-4903.

2. Koike M, Iino M, Ozawa S. Blocking effect of 1-naphthyl acetyl spermine on Ca2+-permeable AMPA receptors in cultured rat hippocampal neurons. Neuroscience Research, 1997, 29(1): 27-36.