Rofecoxib D5 (MK 966 D5) 是氘标记的 Rofecoxib。
| Cas No. | 544684-93-7 |
| 别名 | 罗非考昔 d5 |
| Canonical SMILES | O=C1OCC(C2=CC=C(S(C)(=O)=O)C=C2)=C1C3=C([2H])C([2H])=C([2H])C([2H])=C3[2H] |
| 分子式 | C17H9D5O4S |
| 分子量 | 319.4 |
| 溶解度 | Acetonitrile: soluble,DMSO: soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Rofecoxib-d5 is intended for use as an internal standard for the quantification of rofecoxib by GC- or LC-MS. Rofecoxib is a non-steroidal anti-inflammatory drug (NSAID) that selectively inhibits COX-2 over COX-1 with IC50 values of 0.018 and >15 μM, respectively, for production of prostaglandin E2 in CHO cells expressing the recombinant human enzymes.1 In vivo, rofecoxib inhibits carrageenan-induced paw edema and hyperalgesia (ID50s = 1.5 and 1.0 mg/kg, respectively), LPS-induced pyresis (ID50 = 0.24 mg/kg), and M. butyricum-induced arthritis (ID50 = 0.74 mg/kg per day) in rats. Formulations containing rofecoxib were previously used in the treatment of pain and arthritis. |
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