| CAS NO: | 350992-13-1 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| Cas No. | 350992-13-1 |
| 别名 | 7-[4-([1,1'-联苯]-3-甲基)-1-哌嗪基]-2(3H)H-苯并恶唑酮甲磺酸 |
| Canonical SMILES | O=C1NC2=CC=CC(N3CCN(CC4=CC(C5=CC=CC=C5)=CC=C4)CC3)=C2O1.CS(=O)(O)=O |
| 分子式 | C24H23N3O2.CH3SO3H |
| 分子量 | 481.6 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Bifeprunox is an atypical antipsychotic.1 It is a dopamine D2 receptor partial agonist and an agonist of the serotonin (5-HT) receptor subtype 5-HT1A (Kis = 2.2 and 9.3 nM, respectively).2,3 Bifeprunox inhibits apomorphine-induced climbing behavior in mice (ED50 = 0.1 mg/kg) and the conditioned avoidance response in rats (ED50 = 0.8 mg/kg).3 It decreases basal prepulse inhibition of the acoustic startle response in rats by 42% when administered at a dose of 10 mg/kg.2 |1. Wadenberg, M.-L.G. Bifeprunox: A novel antipsychotic agent with partial agonist properties at dopamine D2 and serotonin 5-HT1A receptors. Future Neurol. 2(2), 153-165 (2007).|2. Auclair, A.L., Galinier, A., Besnard, J., et al. Putative antipsychotics with pronounced agonism at serotonin 5-HT1A and partial agonist activity at dopamine D2 receptors disrupt basal PPI of the startle reflex in rats. Psychopharmacol. (Berl). 193(1), 45-54 (2007).|3. Feenstra, R.W., de Moes, J., Hofma, J.J., et al. New 1-aryl-4-(biarylmethylene)piperazines as potential atypical antipsychotics sharing dopamine D2-receptor and serotonin 5-HT1A-receptor affinities. Bioorg. Med. Chem. Lett. 11(17), 2345-2349 (2001). |
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