| CAS NO: | 1432062-16-2 |
| 包装 | 价格(元) |
| 500 μg | 电议 |
| 1mg | 电议 |
| Cas No. | 1432062-16-2 |
| 别名 | Meclozine-d8 dihydrochloride |
| Canonical SMILES | CC1=CC=CC(CN(C([2H])([2H])C2([2H])[2H])C([2H])([2H])C([2H])([2H])N2C(C3=CC=CC=C3)C4=CC=C(Cl)C=C4)=C1.Cl.Cl |
| 分子式 | C25H19ClD8N2.2HCl |
| 分子量 | 471.9 |
| 溶解度 | Chloroform: slightly soluble,Methanol: slightly soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Meclizine-d8is intended for use as an internal standard for the quantification of meclizine by GC- or LC-MS. Meclizine is a histamine H1receptor antagonist (Ki= 250 nM).1Pretreatment with meclizine (2.5-30 mg/kg, i.p.) reduces ovalbumin-induced mast cell degranulation, edema, and leukocyte influx in rat lung.2Formulations containing meclizine have been used in the treatment of motion sickness and vertigo. 1.Tran, V.T., Chang, R.S.L., and Snyder, S.H.Histamine H1 receptors identified in mammalian brain membranes with [3H]mepyramineProc. Natl. Acad. Sci. U.S.A.75(12)6290-6294(1978) 2.Pasquale, C.P., e Silva, P.M., Lima, M.C., et al.Suppression by cetirizine of pleurisy triggered by antigen in actively sensitized ratsEur. J. Pharmacol.223(1)9-14(1992) |
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