(R)-(+)-Etomoxir sodium salt

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CAS NO:

828934-41-4

包装与价格：

包装	价格(元)
10mM (in 1mL DMSO)	电议
10mg	电议
50mg	电议

产品介绍

化学性质

Physical Appearance	A solid
Storage	Store at -20°C
M.Wt	320.74
Cas No.	828934-41-4
Formula	C₁₅H₁₈ClNaO₄
Solubility	insoluble in H2O; insoluble in EtOH; ≥12 mg/mL in DMSO
Chemical Name	sodium (R)-2-(6-(4-chlorophenoxy)hexyl)oxirane-2-carboxylate
Canonical SMILES	ClC1=CC=C(C=C1)OCCCCCC[C@@]2(C([O-])=O)OC2.[Na+]
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

(R)-(+)-Etomoxir sodium salt is an irreversible inhibitor of carnitine palmitoyltransferase 1(CPT-1)[1].

Etomoxir (100 μM) has no effect on T cells cultured in high glucose. In contrast, there is a significant increase in apoptosis in etomoxir-treated cultures stimulated with antigen under low glucose conditions[2].

C57BL/6 mice treated with Etomoxir (15 mg/kg, i.p) reduce the infiltration of immune cells in the central nervous system. Only a small number of macrophages, activated microglia or T cells are present, while reducing the inflammatory response and Demyelinating reaction[2].

References:

[1]. Rupp H, Zarain-Herzberg A, Maisch B. The Use of Partial Fatty Acid Oxidation Inhibitors for Metabolic Therapy of Angina Pectoris and Heart Failure. Herz, 2002, 27(7): 621-636.

[2]. Shriver L P, Manchester M. Inhibition of fatty acid metabolism ameliorates disease activity in an animal model of multiple sclerosis. Scientific Reports, 2011, 1.

试验操作

Cell experiment:[1]
Cell lines	Splenocytes isolated from C57BL/6 mice immunized with myelin oligodendrocyte glycoprotein (MOG_35-55) peptide
Reaction Conditions	100 μM etomoxir for 72 h incubation
Applications	Etomoxir exhibited no effect on MOG_35-55-specific T cells cultured in high glucose conditions in terms of pro-inflammatory cyokine production and apoptosis. In contrast, there were a significant reduction in IFN-γ production and a substantial increase in apoptosis in etomoxir-treated cultures stimulated with antigen under low glucose conditions.
Animal experiment:[1]
Animal models	A mouse model of multiple sclerosis
Dosage form	15 mg/kg Injected intraperitoneally on days 8 and 15 after experimental autoimmune encephalomyelitis (EAE) induction
Applications	Etomoxir-treated mice displayed a reduced immune cell infiltration in the central nervous system with few macrophages, activated microglia, or T cells present. Etomoxir treatment also alleviated inflammation and prevented myelin destruction in spinal cords.
Note	The technical data provided above is for reference only.
	References: 1. Shriver LP, Manchester M. Inhibition of fatty acid metabolism ameliorates disease activity in an animal model of multiple sclerosis. Scientific Reports, 2011, 1: 79.