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PD-159020
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PD-159020图片
CAS NO:177904-00-6
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
20mg电议

产品介绍
PD-159020是一种非选择性的ETA/ETB拮抗剂,对hETA和hETB的IC50值分别为30和50nM。
Cas No.177904-00-6
Canonical SMILESO=C(C(N1CC2=CC=C(OCO3)C3=C2)=C(C4=CC=C(OCO5)C5=C4)C6=C1C=C(OCC7=CC=CC=C7)C(OC)=C6)O
分子式C32H25NO8
分子量551.54
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

PD-159020 is a non-selective ETA/ETB antagonist, with IC50s of 30 and 50 nM for hETA and hETB, respectively.

PD-159020 demonstrates excellent inhibition of arachidonic acid release, AAR-B, with an IC50 of 0.23 μM.

[1]. Amy Mbunker, et al. 1,3-diaryl-2-carboxyindoles as potent non-peptide endothelin antagonists. Bioorganic & Medicinal Chemistry Letters. Volume 6, Issue 9, 7 May 1996, Pages 1061-1066