| 包装 | 价格(元) |
| 10ug | 电议 |
| 1mg | 电议 |
| Gene ID: | 5008 | Accession #: | P13725 |
| Alternate Names: | Human Oncostatin M, h-Oncostatin M, rh-Oncostatin M, recombinant human Oncostatin M, recombinant Oncostatin M. | ||
| Source: | Escherichia Coli. | M.Wt: | 26.0 kDa |
| Appearance: | Lyophilized protein | Storage: | Store at -20°C |
| Formulation: | Sterile filtered and lyophilized with no additives. | ||
| Solubility: | Reconstitute in water to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or -20°C for future use. | ||
| Shipping Condition: | Gel pack. | Handling: | Centrifuge the vial prior to opening. |
| Usage: | For Research Use Only! Not to be used in humans. | ||
Oncostatin (OSM) is a pleiotropic cytokine produced by activated T cells, monocytes, and Kaposi’ s sarcoma cells. OSM stimulates the proliferation of fibroblasts, smooth muscle cells and Kaposi’s sarcoma cells, inhibits the growth of some normal and tumor cell lines, promotes cytokine release (IL-6, GM-CSF and G-CSF) from endothelial cells, and enhances the expression of low-density lipoprotein receptors in hepatoma cells.
Human OSM cDNA encodes a 252 amino acid pre-pro-OSM polypeptide with a 25 residue signal peptide and a hydrophilic C-terminal domain that are proteolytically processed to generate the 196 residue mature OSM protein. Human OSM is active on murine cells. Recombinant human Oncostatin M is a 26 kDa protein containing 227 amino acid residues.
| Determined by the dose-dependent stimulation of the proliferation of human TF-1 cells. | ||||||
| ED50 | <2 ng/ml. | |||||
| Specific activity | > 5*105units/mg. | |||||
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