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Candesartan-d4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Candesartan-d4图片
CAS NO:1346604-70-3
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
Candesartan D4 (CV-11974 D4) 是氘标记的 Candesartan,它是一种血管紧张素 II 受体拮抗剂。
Cas No.1346604-70-3
别名坎地沙坦 D4; CV-11974-d4
Canonical SMILESOC(C1=CC=CC2=C1N(CC3=C([2H])C([2H])=C(C4=CC=CC=C4C5=NN=NN5)C([2H])=C3[2H])C(OCC)=N2)=O
分子式C24H16D4N6O3
分子量444.5
溶解度DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 3 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Candesartan-d4 is intended for use as an internal standard for the quantification of candesartan by GC- or LC-MS. Candesartan is an inhibitor of the angiotensin II type 1 (AT1) receptor (Kis = 0.17, 0.12, and 0.12 nM for human AT1, rat AT1A, and rat AT1B recombinant receptors, respectively). It is selective for AT1 over AT2 receptors (Ki = 26,500 nM for the human recombinant AT2 receptor). It inhibits angiotensin II-induced contraction of isolated rabbit aortic strips and increases in blood pressure in rats following intravenous administration (ID50 = 0.033 mg/kg). Candesartan is a metabolite of the orally bioavailable prodrug candesartan cilexetil . Formulations containing candesartan have been used in the treatment of hypertension and heart failure.