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Benocyclidine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Benocyclidine图片
CAS NO:112726-66-6
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议

产品介绍

化学性质

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt299.47
Cas No.112726-66-6
FormulaC19H25NS
SolubilitySoluble in DMSO
Chemical Name1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)piperidine
Canonical SMILESC1CCC(CC1)(C2=CC3=CC=CC=C3S2)N4CCCCC4
运输条件蓝冰运输或根据您的需求运输。
一般建议为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。

资料参考

Benocyclidine is an inhibitor of dopamine reuptake [1, 2].

Dopamine plays important roles in the brain and body. In the brain, dopamine functions as a neurotransmitter involved in reward-motivated behavior, motor control and controlling the release of various hormones. Dysfunctions of the dopamine system have been associated several important diseases including Parkinson's disease, attention deficit hyperactivity disorder, schizophrenia, and addiction [3]. Dopamine also functions in blood vessels, kidneys, pancreas, the digestive system, the immune system, and the blood vessels.

Benocyclidine (BTCP) was a derivative of phencyclidine (PCP) with a benzothiophenyl group instead of a phenyl ring. BTCP potently inhibited dopamine (DA) uptake with the IC50 of 7-8 nM. BTCP showed low affinity for the PCP receptor with the IC50 of 6 μM [1, 2]. In the striatum, BTCP binding was dose-dependently inhibited by unlabeled BTCP and nomifensine with the ID50 of 6.34 mg/kg and 11.06 mg/kg, respectively. BTCP bound to the dopamine uptake complex in the mouse brain in vivo [4].

References:
[1] Vignon J, Pinet V, Cerruti C, et al.  [3H] N-[1-(2-Benzo (b) thiophenyl) cycohexyl] piperidine ([3H] BTCP): a new phencyclidine analog selective for the dopamine uptake complex[J]. European journal of pharmacology, 1988, 148(3): 427-436.
[2] Chaudieu I, Vignon J, Chicheportiche M, et al.  Role of the aromatic group in the inhibition of phencyclidine binding and dopamine uptake by PCP analogs[J]. Pharmacology Biochemistry and Behavior, 1989, 32(3): 699-705.
[3] Seeman P.  Brain dopamine receptors[J]. Pharmacological Reviews, 1980, 32(3): 229-313.
[4] Maurice T, Vignon J, Kamenka J M, et al.  In vivo labelling of the mouse dopamine uptake complex with the phencyclidine derivative [3 H] BTCP[J]. Neuroscience letters, 1989, 101(2): 234-238.