| CAS NO: | 156707-43-6 |
| 包装: | 5mg |
| 市场价: | 2520元 |
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 371.5 |
| Cas No. | 156707-43-6 |
| Formula | C15H21N3O4S2 |
| Synonyms | Farnesyltransferase Inhibitor II,FTI-II |
| Solubility | ≤25mg/ml in water |
| Chemical Name | N-[4-[[(2R)-2-amino-3-mercapto-1-oxopropyl]amino]benzoyl]-L-methionine |
| Canonical SMILES | O=C(N[C@H](C(O)=O)CCSC)C1=CC=C(NC([C@@H](N)CS)=O)C=C1 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
FTase Inhibitor II is a potent farnesyl transferase inhibitor.
Protein prenylation is reported as a key mechanism by which functional association of proteins to membranes is mediated. Ras proteins that are regulators of cell proliferation and differentiation are among the proteins undergoing farnesylation.
In vitro: Previous study found that cells were treated with FTase Inhibitor II and two GGTase inhibitors (GGTI-286 and GGTI-2147) and the results showed that there was no change in cell growth in the presence of these inhibitors, even when 100 μM of the drugs were added to the culture. In addition, when cells were treated with a combination of GGTI-2147 and FTase Inhibitor II, ranging from 0.1 nM to 100 μM, cell growth was not affected. Additionally, in the presence of both 50 μM FTase Inhibitor II and 50 μM GGTI-2147, the FTase and GGTase I enzyme activities were abolished [1].
In vivo: Currently, there is no animal in vivo data reported.
Clinical trial: Up to now, FTase Inhibitor II is still in the preclinical development stage.
Reference:
[1] V. Manne, C. S. Ricca, J. G. Brown, et al. Ras farnesylation as a target for novel antitumor agents: Potent and selective farnesyl diphosphate analog inhibitors of farnesyltransferase. Drug Development Research 34, 121-137 (1995).
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