ML-356

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ML-356

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1808260-45-8

包装与价格：

包装	价格(元)
1mg	电议
5mg	电议
10mg	电议

产品介绍

化学性质

Physical Appearance	A crystalline solid
Storage	Store at -20°C
M.Wt	423.5
Cas No.	1808260-45-8
Formula	C₁₉H₂₅N₃O₄S₂
Solubility	≤0.5mg/ml in ethanol;20mg/ml in DMSO;10mg/ml in dimethyl formamide
Chemical Name	2-ethyl-N-[4-[4-(4-morpholinylsulfonyl)phenyl]-2-thiazolyl]-butanamide
Canonical SMILES	O=S(C1=CC=C(C2=CSC(NC(C(CC)CC)=O)=N2)C=C1)(N3CCOCC3)=O
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

ML-356 is an inhibitor of the thioesterase domain of fatty acid synthase with IC50 value of 334 nM.

Fatty acid synthase (FAS) is a multi-enzyme protein that catalyzes fatty acid synthesis, fatty acids are related to energy production and storage, cellular structure ,hormones biosynthesis .A number of subsequent immunohistochemically analyses showed that increased expression of FAS is a hallmark of all major cancers including those of the prostate, the breast, the colon, and the ovaries.

In prostate cancer PC-3 cells, ML-356 blocked palmitate (the final product of fatty acids synthesis) biosynthesis, indicating that ML-356 has potential to block tumor growth in vivo because FAS is up-regulated in all the major solid tumors.

Reference:
1. R. Ardecky, M. P. Hedrick, P. Gosalia, et al. Selective inhibitors of FAS-TE. Probe Reports from the NIH Molecular Libraries Program (2010).