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2-Iminobiotin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
2-Iminobiotin图片
CAS NO:13395-35-2
包装与价格:
包装价格(元)
50mg电议
100mg电议

产品介绍

化学性质

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt243.3
Cas No.13395-35-2
FormulaC10H17N3O2S
SynonymsGuanidinobiotin
SolubilitySoluble in DMSO
Chemical Name(3aR,6S,6aS)-2-amino-3a,4,6,6a-tetrahydro-1H-thieno[3,4-d]imidazole-6-pentanoic acid
Canonical SMILES[H][C@](NC1=N)(CS[C@H]2CCCCC(O)=O)[C@@]2(N1)[H]
运输条件蓝冰运输或根据您的需求运输。
一般建议为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。

资料参考

2-Iminobiotin is a novel, potent, selective inhibitor of neuronal and inducible nitric oxide synthase.

Nitric oxide synthases (NOS) are a family of enzymes catalyzing the five-electron oxidation of L-arginine to citrulline and nitric oxide. NO produced by NOS is an important cellular signaling molecule implicated in modulating vascular tone, airway tone, insulin secretion, and peristalsis, angiogenesis and neural development [2].

In vitro: 2-Iminobiotin is a reversible inhibitor of murine iNOS and rat n-cNOS with the Ki values of 21.8 and 37.5 μM, respectively. The guanidino group of 2-iminobiotin is essential for binding. 2-iminobiotin carboxy derivatives were also inhibitors of iNOS which indicates that the free carboxyl group is not required for binding.

In vivo: A dose of 30 mg/kg per day of 2-iminobiotin after hypoxia-ischemia resulted in significant long-term neuro-protection [3]. 2-iminobiotin (2-IB) reduced hypoxia-ischemia (HI)-induced brain damage in neonatal rats. In P7 rat pups, 2-Iminobiotin treatment reduced long-term brain damage in female but not male rats [4].

References:
[1] Sup S J, Green B G, Grant S K.  2-Iminobiotin is an inhibitor of nitric oxide synthases[J]. Biochemical and biophysical research communications, 1994, 204(2): 962-968.
[2] Moncada S, Palmer R M L, Higgs E A.  Nitric oxide: physiology, pathophysiology, and pharmacology[J]. Pharmacological reviews, 1991, 43(2): 109-142.
[3] Tweel E R W, van Bel F, Kavelaars A, et al.  Long-term neuroprotection with 2-iminobiotin, an inhibitor of neuronal and inducible nitric oxide synthase, after cerebral hypoxia-ischemia in neonatal rats[J]. Journal of Cerebral Blood Flow & Metabolism, 2005, 25(1): 67-74.
[4] Nijboer C H A, Groenendaal F, Kavelaars A, et al.  Gender-Specific Neuroprotection by 2-Iminobiotin after Hypoxia—Ischemia in the Neonatal Rat via a Nitric Oxide Independent Pathway[J]. Journal of Cerebral Blood Flow & Metabolism, 2007, 27(2): 282-292.