| CAS NO: | 17735-98-7 |
| 包装 | 价格(元) |
| 5mg (solution) | 电议 |
| 10mg (solution) | 电议 |
| Physical Appearance | A solution in ethanol. To change the solvent, simply evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice. |
| Storage | Store at -20°C |
| M.Wt | 336.6 |
| Cas No. | 17735-98-7 |
| Formula | C22H40O2 |
| Synonyms | cis-13,16-Docosadienoic Acid |
| Solubility | ≤10mg/ml in ethanol;10mg/ml in DMSO;10mg/ml in dimethyl formamide |
| Chemical Name | 13Z,16Z-docosadienoic acid |
| Canonical SMILES | CCCCC/C=C\C/C=C\CCCCCCCCCCCC(O)=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
13Z,16Z-Docosadienoic acid is a natural ω-6 polyunsaturated fatty acid (PUFA) formed through a 2-carbon chain elongation of arachi donic acid. 13Z,16Z-Docosadienoic acid acts as an agonist of free fatty acid receptor 4 (FFAR4, also known as GPR120) [1].
Free fatty acids act as a source of energy and also function as signaling molecules which involved in regulating energy homeostasis. The endogenous ligands for FFAR4 are ω3-FAs, such as α-LA,DHA and EPA. FFAR4 has been involved in diverse physiological process such as anti-inflammation, insulin sensitization, release of gut peptides and alternation of food preference [2].
13Z,16Z-Docosadienoic acid strongly inhibited the secretion of ghrelin by isolated mouse gastric cells [1]. Dietary n-3 polyunsaturated fatty acids (PUFA) ameliorate several human diseases such as coronary heart disease, autoimmune and inflammatory disorders, diabetes, obesity and cancer [3]. This 20:2 PUFA has already been identified in fish, mammals, plants, and anaerobic fungi.
References:
[1]. X. Lu, X. Zhao, J. Feng, et al. Postprandial inhibition of gastric ghrelin secretion by long-chain fatty acid through GPR120 in isolated gastric ghrelin cells and mice. Am. J. Physiol. Gastrointest. Liver Physiol. 303(3), G367-376 (2012).
[2]. Kimura I. Omega-3 fatty acids and FFAR4[J]. Obesity and Diabetes: Energy Regulation by Free Fatty Acid Receptors, 2016: 29.
[3]. Ma D W L, Seo J, Switzer K C, et al. n-3 PUFA and membrane microdomains: a new frontier in bioactive lipid research[J]. The Journal of nutritional biochemistry, 2004, 15(11): 700-706.
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