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Agnuside
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Agnuside图片
CAS NO:11027-63-7
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
Agnuside 是一种从 Vitex negundo 中分离出来的化合物,可下调促炎介质 PGE2 和 LTB4,并降低细胞因子的表达,具有抗关节炎活性。
Cas No.11027-63-7
别名穗花牡荆苷; Agnoside
Canonical SMILESOC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@](O[C@H]2[C@@](C(COC(C3=CC=C(O)C=C3)=O)=C[C@H]4O)([H])[C@@]4([H])C=CO2)([H])O1
分子式C22H26O11
分子量466.4
溶解度DMF: 10 mg/ml,DMSO: 10 mg/ml,Ethanol: 0.5 mg/ml,PBS (pH 7.2): 0.2 mg/ml
储存条件4°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Agnuside is an iridoid glycoside originally isolated from V. rotundifolia fruit that has diverse biological activities. It inhibits COX-2 with an IC50 value of 0.026 mg/ml but exhibits less than 10% inhibition of COX-1 at this concentration. It also inhibits 46.3, 66.8, and 82.1% of P-glycoprotein (P-gp) ATPase activity at concentrations of 5, 25, and 100 μM, respectively. Agnuside (0.1-10 μM) induces proliferation of MCF-7 breast cancer cells, an effect that is inhibited by the estrogen receptor antagonist fulvestrant . In vivo, agnuside (50 mg/kg) reduces acetic acid-induced writhing in mice indicating analgesia. It also suppresses production of the pro-inflammatory mediators prostaglandin E2 (PGE2) and leukotriene B4 and the T cell-mediated cytokines IL-2, TNF-α, INF-γ, IL-4, IL-10, and IL-17 in splenocytes and arthritic paw tissue from arthritic adrenalectomized rats.