拉坦前列素（游离酸）是前列腺素 (PG) F2α 的类似物；是一种选择性前列腺素受体 (FP) 激动剂，可特异性激活 FP-PG 受体。
| Cas No. | 41639-83-2 |
| 别名 | 拉坦前列腺素(游离酸) |
| Canonical SMILES | O[C@@H]1[C@H](C/C=C\CCCC(O)=O)[C@@H](CC[C@@H](O)CCC2=CC=CC=C2)[C@H](O)C1 |
| 分子式 | C23H34O5 |
| 分子量 | 390.5 |
| 溶解度 | DMF: >100 mg/ml (from Fluprostenol),DMSO: >100 mg/ml (from Fluprostenol),Ethanol: >100 mg/ml (from Fluprostenol),PBS pH 7.2: >0.8 mg/ml (from 17-phenyl tri |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Latanoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug. Latanoprost is an isopropyl ester, a prodrug form which is converted to latanoprost (free acid) by endogenous esterase enzymes. The free acid form is 200 times more potent than latanoprost as an FP receptor ligand for the human recombinant FP receptor. Latanoprost is the isopropyl ester of a PGF2α analog containing an aromatic group (17-phenyl) in the ω-chain. Lat-FA is the corresponding carboxylic acid of this analog. Lat-FA is a potent FP receptor agonist with an EC50 of 3.6 nM for human FP receptors, which is twice the potency of PGF2α. The efficacy of PG analog esters for the treatment of glaucoma correlates closely with the FP receptor binding affinity of the free acid. However, Lat-FA is more irritating and less effective than the prodrug latanoprost when applied directly to the eyes of human glaucoma patients. |
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