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Antileukinate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Antileukinate图片
CAS NO:138559-60-1
包装与价格:
包装价格(元)
500μg电议
1mg电议
5mg电议

产品介绍
Antileukinate 是一种六肽,是一种有效的 CXC 趋化因子受体 (CXCR) 抑制剂。
Cas No.138559-60-1
Canonical SMILESCC(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC1=CNC2=C1C=CC=C2)C(N[C@@H](CC3=CNC4=C3C=CC=C4)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N)=O)=O)CS)=O)=O)=O)=O)CCCNC(N)=N)=O
分子式C45H66N18O7S
分子量1003.2
溶解度DMF: 1 mg/ml,DMSO: 5 mg/ml,PBS (pH 7.2): 2 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Antileukinate is a synthetic hexapeptide with an acetylated amino terminus and an amidated carboxyl terminus that inhibits the binding of CXC chemokines to the chemokine receptor CXCR2. It inhibits IL-8 binding to neutrophils (Ki = 2.7-13 µM), prevents neutrophil chemotaxis and β-glucuronidase release, and blocks IL-8-induced skin edema in rabbits. At 53 mg/kg, antileukinate has been shown to protect mice against acute pancreatitis and associated lung injury.