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Artemether(SM-224)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Artemether(SM-224)图片
CAS NO:71963-77-4
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍

Semi-synthetic derivative of artemisinin

Cas No.71963-77-4
别名蒿甲醚; Dihydroqinghaosu methyl ether; Dihydroartemisinin methyl ether; SM224
化学名(3R,5aS,6R,8aS,9R,10S,12R,12aR)-10-methoxy-3,6,9-trimethyldecahydro-3H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene
Canonical SMILES[H][C@]12[C@@]3([C@@]4([H])CC[C@@]2([H])C)[C@@](O[C@H](OC)[C@@]4(C)[H])([H])O[C@@](OO3)(C)CC1
分子式C16H26O5
分子量298.4
溶解度≥ 15.3 mg/mL in DMSO, ≥ 90.2 mg/mL in EtOH
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Artemether is a semi-synthetic derivative of artemisinin (qinghaosu), a naturally occurring peroxide lactone derived from a traditional Chinese herbal remedyArtemisia annuaL., to enhance the solubility and antimalarial activity of its parental compound. Artemether exhibits potent antimalarial and antischistosomal activities against malarial parasites andSchistosoma japonicuminfections. Although it has not been well elucidated, an endoperoxide bridge within the chemical structure of Artemether might be the key characteristic considered to be responsible for its antimalarial and antischistosomal activities, which can be metabolized by malarial or schistosomal parasites, underin vivoconditions, generating detrimental oxygen radicals to attack parasite macromolecules.

Reference

[1].Xiao Shuhua and Brian A. Catto. In vitro and in vivo studies of the effect of artemether on Schistosoma mansoni. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 1989, 1557-1562