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R-Palmitoyl-(1-methyl)Ethanolamide
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
R-Palmitoyl-(1-methyl)Ethanolamide图片
CAS NO:142128-47-0
包装与价格：
包装价格(元)
50mg电议
500mg电议

产品介绍

化学性质

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt313.5
Cas No.142128-47-0
FormulaC19H39NO2
SynonymsR-1 PMA
Solubility≤10mg/ml in ethanol;25mg/ml in DMSO;3.3mg/ml in dimethyl formamide
Chemical NameN-(2-hydroxy-1R-methylethyl)-hexadecanamide
Canonical SMILESCCCCCCCCCCCCCCCC(=O)N[C@H](C)CO
运输条件蓝冰运输或根据您的需求运输。
一般建议为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

R-Palmitoyl-(1-methyl) ethanolamide, a synthetic analog of Palmitoyl ethanolamide (PEA), incorporates the (R)-methyl group vicinal to the alcohol on the ethanolamine moiety. The analogous modification to arachidonoyl ethanolamide (AEA) protects the molecule from hydrolysis by fatty acid amide hydrolase, prolongs duration of action and enhances potency in vivo [1].

PEA is an endogenous cannabinoid existed in mammalian tissues, such as liver and brain. PEA has also been isolated from egg yolk [2, 3]. PEA is a compound with documented anti-nociceptive and anti-inflammatory effects. During inflammation, PEA is accumulated and exihibits anti-inflammatory effects, including beneficial effects in clinically relevant animal models of inflammatory pain [4].

References:
[1] Abadji V, Lin S, Taha G, et al.  (R)-methanandamide: a chiral novel anandamide possessing higher potency and metabolic stability[J]. Journal of medicinal chemistry, 1994, 37(12): 1889-1893.
[2] Bachur N R, Masek K, Melmon K L, et al.  Fatty acid amides of ethanol-amine in mammalian tissues[J]. Journal of Biological Chemistry, 1965, 240: 1019-1024.
[3] Ganley O H, Graessle O E, Robinson H J, et al.  Anti-inflammatory activity of compounds obtained from egg yolk, peanut oil, and soybean lecithin[J]. Journal of Laboratory and Clinical Medicine, 1958, 51: 709-714.
[4] Lambert D M, Vandevoorde S, Jonsson K O, et al.  The palmitoylethanolamide family: a new class of anti-inflammatory agents [J]. Current medicinal chemistry, 2002, 9(6): 663-674.