| CAS NO: | 79356-08-4 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 25mg | 电议 |
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 917.1 |
| Cas No. | 79356-08-4 |
| Formula | C47H80O17 |
| Synonyms | Antibiotic X 14868A |
| Solubility | Soluble in DMSO |
| Chemical Name | (2R,3S,4S,5R,6S)-6-[(1R)-1-[(2S,5R,7S,8R,9S)-2-[(2S,2'R,3'S,5R,5'R)-3'-[(2,6-dideoxy-3,4-di-O-methyl-β-L-arabino-hexopyranosyl)oxy]octahydro-2-methyl-5'-[(2S,3S,5R,6S)-tetrahydro-6-hydroxy-3,5,6-trimethyl-2H-pyran-2-yl][2,2'-bifuran]-5-yl]-9-hydroxy-2,8-d |
| Canonical SMILES | CO[C@@H]1[C@@H](OC)[C@H](C)O[C@@](O[C@@H]2[C@@]([C@]3(C)CC[C@@]([C@@]4(C)O[C@@]5(C[C@H](O)[C@@H](C)[C@]([C@@H](C)[C@]6([H])O[C@@](CC(O)=O)(O)[C@@H](C)[C@H](OC)[C@H]6OC)([H])O5)CC4)([H])O3)([H])O[C@]([C@]7([H])[C@@H](C)C[C@@H](C)[C@@](C)(O)O7)([H])C2) |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
IC50: 20.7 μM: inhibits ATP synthesis in spinach chloroplasts [1].
IC50: 96.6 μM: blocks H+ uptake in spinach chloroplasts [1].
Maduramicin, a natural polyether antibiotic, is cytotoxic against Cryptosporidium spp. and Plasmodium gametocytes, isolated from the actinomycete Actinomadura rubra. As a broad-spectrum anticoccidial, maduramicin, which is commonly used in veterinary medicine as an anti-coccidial agent, is active against Treponema and Cryptosporidium. Maduramicin is an ionophore which can form complexes with monovalent cations with a higher affinity for K+ than Na+.
In vitro: Maduramicin concentration-dependently blocked cell growth and inhibited cell proliferation in a concentration- and time-dependent fashion in skeletal muscle cells, mouse myoblasts (C2C12) and human rhabdomyosarcoma (RD and Rh30) cells. Also, maduramicin triggered cleavage of poly ADP ribose polymerase in a concentration-dependent manner, which was the hallmark of caspase-dependent apoptosis in C2C12 and RD cells. It was determined that maduramicin caused cell death via caspase-dependent and -independent manner in C2C12 cells [2].
In vivo: Severe combined immune deficient (SCID) mice were administered with maduramicin at 3 mg/kg of body weight per day by oral gavage for 28 days. Maduramicin treatment decreased the fecal parasite load after 21 days of treatment. Also, maduramicin treatment elicited weight loss in SCID mice. In addition, Maduramicin exerted remarkable anticryptosporidial activities with concomitant moderate toxicity on SCID mice [3].
References:
[1]. Gutiérrez-Lugo, M., Lotina-Hennsen, B., Farrés, A., Sánchez, S., & Mata, R. Phytotoxic and Photosynthetic Activities of Maduramicin and Maduramicin Methyl Ester. Zeitschrift Für Naturforschung C. 1999; 54(5-6).
[2]. Chen, X., Gu, Y., Singh, K., Shang, C., Barzegar, M., Jiang, S., & Huang, S. Maduramicin Inhibits Proliferation and Induces Apoptosis in Myoblast Cells. Plos ONE.2014; 9(12): e115652.
[3]. Mead, J., You, X., Pharr, J., Belenkaya, Y., Arrowood, M., Fallon, M., & Schinazi, R. Evaluation of maduramicin and alborixin in a SCID mouse model of chronic cryptosporidiosis. Antimicrobial Agents and Chemotherapy. 1995; 39(4): 854-858.
m.cnreagent.com