| CAS NO: | 35189-28-7 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 369.5 |
| Cas No. | 35189-28-7 |
| Formula | C23H31NO3 |
| Synonyms | Dexnorgestrel acetime |
| Solubility | ≤2mg/ml in ethanol;14mg/ml in DMSO;16mg/ml in dimethyl formamide |
| Chemical Name | (17α)-17-(acetyloxy)-13-ethyl-18,19-dinorpregn-4-en-20-yn-3-one 3-oxime |
| Canonical SMILES | CC[C@@]12[C@](CC[C@@]2(OC(C)=O)C#C)([H])[C@]3([H])CCC4=C/C(CC[C@]4([H])[C@@]3([H])CC1)=N/O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
Norgestimate is a synthetic progesterone analog.
Progesterone, an endogenous steroid and progestogen sex hormone, is involved in the pregnancy, menstrual cycle, and embryogenesis. Progesterone is reported to belong to steroid hormones, and is the major progestogen in the body. Progesterone is also a crucial metabolic intermediate in the production of other endogenous steroids and plays an key role in brain function as a neurosteroid.
In vitro: Norgestimate was found that, unlike other 19-nortestosterone derivatives, showed high selectivity for the progesterone receptor and low androgenic activity. Moreover, norgestimate and its main active metabolite norelgestromin could not bind to or occupy sex hormone-binding globulin [1].
In vivo: The androgenic and the progestational activity of norgestimate were compared in two animal studies. It was found the difference in the pharmacological response in norgestimate treated rats was equivalent to the difference in the exposure of the animals to either directly administered or metabolically derived levonorgestrel [2].
Clinical trial: Norgestimate (brand names Ortho-Cyclen, Ortho Tri-Cyclen, Previfem, Sprintec, Prefest, others) is a steroidal progestin of the 19-nortestosterone group that is clinically used in combination with ethinylestradiol and in combination with estradiol in menopausal hormone replacement therapy [3].
References:
[1] Thomas L. Lemke; David A. Williams (2008). Foye's Principles of Medicinal Chemistry. Lippincott Williams & Wilkins. pp. 1316–. ISBN 978-0-7817-6879-5.
[2] Kuhnz W, Beier S. Comparative progestational and androgenic activity of norgestimate and levonorgestrel in the rat. Contraception. 1994 Mar;49(3):275-89.
[3] https://en. wikipedia.org/wiki/Norgestimate
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