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all-trans Retinal
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
all-trans Retinal图片
CAS NO:116-31-4
包装与价格:
包装价格(元)
250mg电议
500mg电议
1g电议

产品介绍

化学性质

StorageStore at -20°C
M.Wt284.4
Cas No.116-31-4
FormulaC20H28O
SynonymsRetinaldehyde,Vitamin A aldehyde
Solubilityinsoluble in H2O; ≥56.6 mg/mL in EtOH; ≥57.4 mg/mL in DMSO
Chemical Nameretinal
Canonical SMILESCC1=C(/C=C/C(C)=C/C=C/C(C)=C/C([H])=O)C(C)(C)CCC1
运输条件蓝冰运输或根据您的需求运输。
一般建议为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。

资料参考

All-trans Retinal, also known as Vitamin A aldehyde or Retinaldehyde, is one of the many forms of vitamin A and also the oxidation product of all-trans retinol [1]. All-trans Retinal are associated with one of the two isoforms of cellular retinol-binding proteins (CRBP-I and CRBP-II) with Kd values of 50 and 90 nM, respectively [1].

CRBP-I and CRBP-II were the first intracellular retinoid-binding proteins. Both proteins display a similar binding affinity towards retinal. They play important roles in retinoid biology and regulation of the metabolism of retinol and retinal. CRBP-I is used to regulate vitamin A storage and synthesis of retinoic acid. And CRBP-II has a role in the initial processing of retinol from food [1].

All-trans Retinal is one form of vitamin A. All-trans Retinal, the initial substrate of retinoid cycle, is a chemically reactive aldehyde that can form toxic conjugates with proteins and lipids, leading to degeneration of the retina [2].

References:
[1].  Noy N. Retinoid-binding proteins: mediators of retinoid action. Biochem J. 2000 Jun 15;348 Pt 3:481-95.
[2].  Kiser PD, Golczak M, Maeda A, et al. Key enzymes of the retinoid (visual) cycle in vertebrate retina. Biochim Biophys Acta. 2012 Jan;1821(1):137-51.