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N-Octadecyl-N'-propyl-sulfamide
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
N-Octadecyl-N'-propyl-sulfamide图片
CAS NO:925891-74-3
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍

化学性质

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt390.7
Cas No.925891-74-3
FormulaC21H46N2O2S
Solubility≤0.2mg/ml in ethanol
Chemical NameN-octadecyl-N'-propyl-sulfamide
Canonical SMILESCCCCCCCCCCCCCCCCCCNS(=O)(=O)NCCC
运输条件蓝冰运输或根据您的需求运输。
一般建议为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

N-Octadecyl-N'-propyl-sulfamide is a potent activator of PPARα with EC50 value of 100 nM [1].

Peroxisome proliferator-activated receptors (PPARs) are members of a superfamily of nuclear hormone receptors with three isoforms PPARα, PPARγ and PPARδ. These ligand-activated transcription factors play important roles in the regulation of lipid and glucose metabolism, and are interesting targets useful in diseases related to altered metabolism such as diabetes, dyslipidemia and obesity [1].

N-Octadecyl-N'-propyl-sulfamide, an analog of oleoylethanolamide (OEA), is a potent hypolipidemic compound and a potent feeding suppressant. N-Octadecyl-N'-propyl-sulfamide is a concentration-dependent activator of PPARα with EC50 value of 100 nM. In MCF-7 cells transfected with human PPARα, N-Octadecyl-N'-propyl-sulfamide exhibited potent and selective PPARα subtype transactivation activity [1][2].

In 24-h food-deprived Wistar rats, i.p. injection of N-Octadecyl-N'-propyl-sulfamide (1 mg/kg) reduced body weight and produced a marked reduction in plasma triglycerides, which were similar to the effects of OEA. In genetically obese Zucker (fa/fa) rats, i.p. injection of N-Octadecyl-N'-propyl-sulfamide (1 mg/kg) reduced body weight gain and food intake [1].

References:
[1].  Cano C, Pavón J, Serrano A, et al. Novel sulfamide analogs of oleoylethanolamide showing in vivo satiety inducing actions and PPARalpha activation. J Med Chem. 2007 Jan 25;50(2):389-93.
[2].  Fu J1, Gaetani S, Oveisi F, et al. Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha. Nature. 2003 Sep 4;425(6953):90-3.