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HQNO
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
HQNO图片
CAS NO:341-88-8
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议

产品介绍

化学性质

StorageStore at -20°C
M.Wt259.34
Cas No.341-88-8
FormulaC16H21NO2
SynonymsKF8940,N-oxo-2-heptyl-4-Hydroxyquinoline,Pyo II
Solubility≥25.9 mg/mL in ETOH with gentle warming; insoluble in H2O; ≥2.48 mg/mL in DMSO with gentle warming and ultrasonic
Chemical Name2-heptyl-1-hydroxyquinolin-4(1H)-one
Canonical SMILESCCCCCCCC1=CC(C2=CC=CC=C2N1O)=O
运输条件蓝冰运输或根据您的需求运输。
一般建议为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。

资料参考

HQNO is a NADH oxidase inhibitor.

The NADPH oxidase, a membrane-bound enzyme complex facing the extracellular space, can be found in the plasma membrane and in the membranes of phagosomes used by neutrophil white blood cells to engulf microorganisms. Isoforms are designated NOX1, NOX2, NOX3, as well as NOX4.

In vitro: Previous study found that HQNO could inhibit the Na+-dependent NADH oxidase but had very limited effect on the NA+-independent activity of mutant membranes. Moreover, the NADH:quinone oxidoreductase was observed to be the Na+-dependent HQNO-sensitive site of the NADH oxidase. In addition, HQNO was found to be able to cause a strong inhibition of the Na+ pump with limited effect on the overall H+ extrusion by respiration in the wild type cells. The inhibition of the Na+ pump by HQNO could be overcome by oxidized but not reduced TMPD. The electron flow NADH to oxygen appeared to bypass the HQNO-sensitive site and energize the Na+ pump in the presence of oxidised TMPD [1].

In vivo: Up to now, there is no animal in vivo data reported.

Clinical trial: So far, no clinical study has been conducted.

Reference:
[1] Tokuda, H. , and Unemoto, T. Na+ is translocated at NADH:quinone oxidoreductase segment in the respiratory chain of Vibrio alginolyticus. The Journal of Biological Chemisty 259(12), 7785-7790 (1984).