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PDM 11
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PDM 11图片
CAS NO:1032508-03-4
包装与价格:
包装价格(元)
25mg电议
50mg电议
100mg电议

产品介绍

化学性质

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt274.7
Cas No.1032508-03-4
FormulaC16H15ClO2
Solubility≤2mg/ml in ethanol;20mg/ml in DMSO;30mg/ml in dimethyl formamide
Chemical Name(E)-5-[2-(4-chlorophenyl)ethenyl]-1,3-dimethoxyphenyl
Canonical SMILESClC(C=C1)=CC=C1/C=C/C2=CC(OC)=CC(OC)=C2
运输条件蓝冰运输或根据您的需求运输。
一般建议为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。

资料参考

PDM 11 is a potent and selective aryl hydrocarbon receptor (AhR) antagonist.

Aryl hydrocarbon receptor (AhR), a ligand-dependent intracellular transcription factor, has ligands including the most infamous xenobiotics, such as benzo[a]pyrene, dioxin, and plenty of polyaromatics.

In vitro: In a previous study, PDM 11 was found to be structurally very similar to several resveratrol analogs which acted as a potent and selective AhR antagonists and agonists. One of these compounds with fluorine in place of the 4'-chlorine of PDM11 was shown to act as a AhR antagonist with a Ki of about 3 nM. This fluorine-containing compound was found to be inactive as a ligand for the estrogen receptor at even up to 100 μM. Therefore, since AhR knockout mice have been reported to be insensitive to the carcinogenic effects of classical AhR ligands, antagonists of AhR might potentially serve as therapeutic agents for the treatment for dioxin and other aryl hydrocarbon poisonings [1].

In vivo: Up to now, there is no animal in vivo data reported.

Clinical trial: So far, no clinical study has been conducted.

Reference:
[1] de Medina, P. ,Casper, R.,Savouret, J.F., et al. Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators. Journal of Medicinal Chemistry 48, 287-291 (2005).