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Cefapirin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Cefapirin图片
CAS NO:21593-23-7
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍

化学性质

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt423.5
Cas No.21593-23-7
FormulaC17H17N3O6S2
SynonymsCefadyl,Cephapirin
Solubility≤10mg/ml in DMSO;5mg/ml in dimethyl formamide
Chemical Name(6R,7R)-3-[(acetyloxy)methyl]-8-oxo-7-[[(4-pyridinylthio)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Canonical SMILESO=C(N[C@@H]1C(N2[C@]1([H])SCC(COC(C)=O)=C2C(O)=O)=O)CSC3=CC=NC=C3
运输条件蓝冰运输或根据您的需求运输。
一般建议为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。

资料参考

Cefapirin is the first generation cephalosporin antibiotic. Cefapirin is broadly effective against gram-negative and gram-positive bacteria [1].

The antibacterial action of cefapirin was due to the inhibition of cell-wall synthesis, mediated by its binding to penicillin binding proteins. It was mainly used in veterinary medicine for intramammary treatment of mastitis and intrauterine treatment of endometritis in cattle [1,2].

Cefapirin was an antibiotic particularly suitable for the treatment of acute otitis media. In 210 strains isolated from the auricular exudate of childrens' acute otitis media, the MIC50 and MIC90 of cefapirin were 2 and 4 mg/l for 112 strains of Haemophilus. The MIC ranged from 0.25 to 4 mg/l for ten strains of Branhamella catarrhalis (9 secreted a beta-lactamase). Cefapirin had an extremely high activity with MIC50 and 90 less than 0.06 mg/l against Streptococcus pneumoniae. For the strains of Staphylococcus aureus sensitive to meticillin, one had a MIC less than 0.06 mg/l, and 11 had a MIC of 0.25 mg/l. For 14 strains of Enterobacteriaceae studied, the MIC 50 was 8 mg/l and the MIC 90 was 32 mg/l [3].

References:
[1] Committee for veterinary medicinal products: Cefapririn.  EMEA, 1-6 (2001).
[2] Ray, P. ,Knowlton, K.F.,Shang, C., et al. Development and validation of a UPLC-MS/MS method to monitor cephapirin excretion in dairy cows following intramammary infusion. PLoS One 9(11), 1-12 (2014).
[3] Simonet M, Herrmann J L, Gehanno P, et al.  Activity of cefapirin against bacterial strains isolated from acute otitis media in children[J]. Pathologie-biologie, 1990, 38(5): 352-354.