| CAS NO: | 108294-57-1 |
| 包装: | 50mg |
| 市场价: | 1274元 |
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 392.5 |
| Cas No. | 108294-57-1 |
| Formula | C9H8Cl2IN3·HCl |
| Solubility | ≤1mg/ml in ethanol;1mg/ml in DMSO;0.25mg/ml in dimethyl formamide |
| Chemical Name | N-(2,6-dichloro-4-iodophenyl)-4,5-dihydro-1H-imidazol-2-amine, monohydrochloride |
| Canonical SMILES | ClC1=CC(I)=CC(Cl)=C1NC2=NCCN2.Cl |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
p-iodo-Clonidine (hydrochloride) is a partial agonist of the alpha 2-adrenergic receptor [1].
The adrenergic receptors are G protein-coupled receptors that are targets of the catecholamines, especially norepinephrine and epinephrine. There are two main groups of adrenergic receptors: α receptors and β receptors. α2-adrenergic receptor is a Gi coupled receptor, which causes a decrease in neurotransmitter release, as well as a decrease of cAMP activity resulting in smooth muscle contraction [1].
p-iodo-Clonidine (hydrochloride) is a partial agonist of the alpha 2-adrenergic receptor. Clonidine is an antihypertensive α2-adrenergic receptor agonist. PIC had minimal agonist activity in inhibiting adenylate cyclase in platelet membranes through α2-adrenergic receptor, but it increased platelet aggregation induced by ADP with EC50 value of 1.5 μM. PIC also inhibited epinephrine-induced aggregation with IC50 value of 5.1 μM. PIC competed for [3H]bromoxidine binding with Ki value of 1.0 nM. PIC bound to the alpha 2B-AR in NG-10815 cell membranes with Kd value of 0.5 +/- 0.1 nM [1].
Reference:
[1]. Gerhardt MA, Wade SM, Neubig RR. p-[125I]iodoclonidine is a partial agonist at the alpha 2-adrenergic receptor. Mol Pharmacol. 1990 Aug;38(2):214-21.
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