| CAS NO: | 13488-22-7 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 300.4 |
| Cas No. | 13488-22-7 |
| Formula | C20H28O2 |
| Synonyms | 5,8,11-ETI |
| Solubility | ≤20mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide |
| Chemical Name | 5,8,11-eicosatriynoic acid |
| Canonical SMILES | CCCCCCCCCCCCCCCCCCCC(=O)O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
5,8,11-Eicosatriynoic Acid is a selective inhibitor of lipoxygenases with ID50 values of 24 μM and 340 μM for n-8 lipoxygenase and fatty acid cycle-oxygenase , respectively[1][2].
Fatty acid cycle-oxygenase and n-8 lipoxygenase catalyze the initial reactions which lead to the formation of three major arachidonic acid metabolites in human platelets. In several tissues, these two enzymes act concomitantly on arachidonic acid [1].
5,8,11-Eicosatriynoic Acid (5,8,11-ET) is a selective inhibitor of lipoxygenases with ID50 values of 24 μM and 340 μM for n-8 lipoxygenase and fatty acid cycle-oxygenase, respectively. 5,8,11-Eicosatriynoic acid was useful for studies on physiological and pathophysiological roles of 12 L-hydroxy-5,8,10,14-eicosatetraenoic acid formation in various tissues [1]. In mouse mastocytoma cells, 5,8,11-Eicosatriynoic Acid inhibited A23187 and L-cysteine induced leukotriene C (LTC4) biosynthesis with ID50 value of 5 μM [2].
References:
[1]. Hammarstrm S. Selective inhibition of platelet n-8 lipoxygenase by 5,8,11-eicosatriynoic acid. Biochim Biophys Acta. 1977 Jun 22;487(3):517-9.
[2]. Orning L, Hammarstrm S. Inhibition of leukotriene C and leukotriene D biosynthesis. J Biol Chem. 1980 Sep 10;255(17):8023-6.
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