| CAS NO: | 9011-18-1 |
| 包装 | 价格(元) |
| 100g | 电议 |
| 500g | 电议 |
| Physical Appearance | A solid |
| Storage | Store at RT |
| M.Wt | 36000-50000 |
| Cas No. | 9011-18-1 |
| Formula | (C6H7Na3O14S3)n |
| Solubility | insoluble in EtOH; insoluble in DMSO; ≥55.5 mg/mL in H2O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
硫酸葡聚糖的钠盐形式可使增加其在水中溶解度且保持稳定。硫酸葡聚糖（DSS）是通过葡聚糖和氯磺酸的酯化反应形成的葡聚糖的聚阴离子衍生物，硫酸葡聚糖含有约17％的硫，相当于每个葡萄糖残基含有约2.3个硫酸根。
炎症性肠病（IBD）是一种慢性复发性胃肠道感染，会增加肠道肿瘤的风险。 1985年首次报道了葡聚糖钠盐（DSS）可用于模拟仓鼠溃疡性结肠炎模型。后续大量研究表明，DSS结肠炎模型与人类溃疡性结肠炎相似。造模时通过改变DDS的浓度和给药频率，可以诱导IBD的急性、慢性和复发模型。
DSS也可用于分子生物学研究，包括脂蛋白沉淀，加速DNA探针与核酸杂交和核糖体分离等应用。
参考文献:
1. Burstein, M., Scholnick, H.R., and Morfin, R. Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions.J. Lipid Res. 11(6), 583-595 (1970).
2. Wahl, G.M., Stern, M., and Stark, G.R. Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate Proc.Natl. Acad. Sci.U.S.A. 76(8), 3683-3687 (1979).
3. Ascione, R., and Arlinghaus, R.B. Characterization and cell-free activity of polyribosomes isolated from baby hamster kidney cells Biochim Biophys.Acta. 204(2), 478-488 (1970).
| Animal experiment:[1] | |
Animal models | Eight-week-old C57BL/6J mice |
Dosage form | 2.5% DDS in drinking water Administered orally for 7 days |
Applications | Oral administration of DDS induced colonic inflammation in a mouse model of inflammatory bowel disease (IBD). Among various chemically induced colitis models, the dextran sulfate sodium-induced colitis model is widely used because of its simplicity and many similarities with human ulcerative colitis. Acute, chronic, and relapsing models of IBD can be achieved by varying the concentration and administration frequency of DDS. |
Note | The technical data provided above is for reference only. |
References: 1. Chassaing B, Aitken JD, Malleshappa M, et al. Dextran sulfate sodium (DSS)-induced colitis in mice. Current Protocols in Immunology, 2014, 104: 15.25.1-15.25.14. | |
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