包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 2019.86 |
Formula | C93H144ClN23O21S2 |
Solubility | ≥24.45 mg/mL in DMSO; ≥47.6 mg/mL in EtOH; ≥89.4 mg/mL in H2O |
Chemical Name | (S)-4-((S)-1-((S)-1-((S)-2-((3S,6S,9S,12R,18S,21S,24S,27S,30S,35aS)-18-((S)-2-((S)-1-((S)-2-acetamido-3-methylbutanoyl)pyrrolidine-2-carboxamido)-3-(3-chlorophenyl)propanamido)-27-(4-aminobutyl)-9-benzyl-30-butyl-24-(3-guanidinopropyl)-6-(hydroxymethyl)-2 |
Canonical SMILES | O=C([C@H](CCC1)N1C([C@H](CCCC)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@@H](NC([C@H](CC2=CC(Cl)=CC=C2)NC([C@H]3N(C([C@H](C(C)C)NC(C)=O)=O)CCC3)=O)=O)CCSSC[C@@H](C(N[C@@H](CCCCN)C(N4[C@@H](CCC4)C(N5[C@@H](CCC5)C(N[C@@H](CCC(O)=O)C(N)=O)=O)=O |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
YAP-TEAD Inhibitor 1 (Peptide 17) is a potent and competitive inhibitor of YAP–TEAD interaction (IC50=25 nM). It has potential application value in YAP related cancer.
Reference:
[1]. Zhang Z, et al. Structure-Based Design and Synthesis of Potent Cyclic Peptides Inhibiting the YAP-TEAD Protein-Protein Interaction.ACS Med Chem Lett, 2014, 5(9): 993-8.