CAS NO: | 88866-92-6 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 985.16 |
Cas No. | 88866-92-6 |
Formula | C44H68N14O10S |
Synonyms | Adrenorphin, Free Acid,H2N-Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-OH |
Solubility | ≥27.75 mg/mL in H2O with ultrasonic; ≥5.64 mg/mL in EtOH with ultrasonic; ≥98.5 mg/mL in DMSO |
Chemical Name | 1-[[4-[2-(azepan-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methylindol-5-ol |
Canonical SMILES | CC(C)C(C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCSC)NC(=O)C(CC1=CC=CC=C1)NC(=O)CNC(=O)CNC(=O)C(CC2=CC=C(C=C2)O)N |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
Adrenorphin (有时也被称为metorphamide)是一个内生的C端酰胺化的类鸦片的八肽,它是由脑啡肽原的蛋白水解产生的,广泛分布在整个哺乳动物大脑里[1]。它是基于最初在来源于肾上腺髓质的人类嗜铬细胞瘤中发现而命名的,后来在正常人类和牛肾上腺髓质也发现了Adrenorphin。Adrenorphin具有有效的类鸦片活性,作为一个平衡的μ-和κ-opioid受体激动剂而对δ-opioid受体没有影响[2]。它具有镇痛和呼吸抑郁的特性[3]。
Figure1 proteolytic cleavage of proenkephalin A
参考文献:
1. Matsuo H, Miyata A, Mizuno K (1983). "Novel C-terminally amidated opioid peptide in human phaeochromocytoma tumour".Nature305 (5936): 721–3.
2. Weber E, Esch FS, Böhlen P et al. (December 1983). "Metorphamide: isolation, structure, and biologic activity of an amidated opioid octapeptide from bovine brain".Proceedings of the National Academy of Sciences of the United States of America80 (23): 7362–6.
3. Xu SF, Lu WX, Zhou KR et al. (April 1985). "The analgesic and respiratory depressant actions of metorphamide in mice and rabbits".Neuropeptides6 (2): 121–31.