BAY1161909

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BAY1161909

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1443763-60-7

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议

产品介绍

化学性质

Storage	Store at -20°C
M.Wt	559.61
Cas No.	1443763-60-7
Formula	C₂₉H₂₆FN₅O₄S
Synonyms	Empesertib
Solubility	≥35 mg/mL in DMSO
Chemical Name	(R)-2-(4-fluorophenyl)-N-(4-(2-((2-methoxy-4-(methylsulfonyl)phenyl)amino)-[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl)propanamide
Canonical SMILES	FC1=CC=C([C@H](C(NC2=CC=C(C3=CN4N=C(N=C4C=C3)NC5=CC=C(S(=O)(C)=O)C=C5OC)C=C2)=O)C)C=C1
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

BAY1161909 is an oral bioavailable selective inhibitor of serine / threonine monopolar spindle 1 (Mps1) kinase with potential antitumor activity. After administration, BAY1161909 binds and inhibits the activity of Mps1, leading to inactivation of spindle assembly checkpoints (SAC), accelerated mitosis, chromosomal misalignment, chromosomal mispolymerization, unstable mitotic checkpoint complexes and increased aneuploidy . This leads to the induction of cell death in cancer cells that overexpress Mps1.