| CAS NO: | 1224606-06-7 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| Storage | Store at -20°C or below |
| M.Wt | 642.09 |
| Cas No. | 1224606-06-7 |
| Formula | C43H79NO2 |
| Synonyms | Dlin-MC3-DMA; DLin |
| Solubility | insoluble in H2O; insoluble in DMSO; ≥152.6 mg/mL in EtOH |
| Chemical Name | (6Z,9Z,28Z,31Z)-heptatriaconta-6,9,28,31-tetraen-19-yl 4-(dimethylamino)butanoate |
| Canonical SMILES | O=C(CCCN(C)C)OC(CCCCCCCC/C=C\C/C=C\CCCCC)CCCCCCCC/C=C\C/C=C\CCCCC |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
siRNA-based drugs need a complicated delivery vehicle, that’s because it degraded rapidly in the circulation, difficult to cross the cell membranes and enter the cytoplasm, plus inefficient accumulation in target tissues. The major delivery technology for siRNA is the lipid nanoparticle (LNP) containing ionizable amino lipid, which is the consisted of an ionizable amino lipid (heptatriaconta-6,9,28,31-tetraen-19-yl 4-(dimethylamino)butanoate, DLin-MC3-DMA), a phosphatidylcholine (1,2-distearoyl-sn-glycero-3-phosphocholine, DSPC), cholesterol and a coat lipid (polyethylene glycol-dimyristolglycerol, PEG-DMG). As a potent siRNA delivery vehicle, DLin-MC3-DMA is 1000-fold more potent for silencing of a hepatic gene (Factor VII), comparing to its precursor lipid DLin-DMA. The ED50 for LNP containing DLin-MC3-DMA to silence Factor VII was 0.005 mg/kg for mice, and 0.03 mg/kg for TTR in non-human primates.
Reference:
Tam YY, Chen S, Cullis PR. Advances in Lipid Nanoparticles for siRNA Delivery. Pharmaceutics. 2013 Sep 18;5(3):498-507. PMID: 24300520.
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