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Fluvastatin Sodium
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Fluvastatin Sodium图片
CAS NO:93957-55-2
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
50mg电议
100mg电议
200mg电议

产品介绍
Fluvastatin sodium (XU 62320) 是第一个完全合成的竞争性 HMG-CoA 还原酶抑制剂,IC50 为 8 nM。
Cas No.93957-55-2
别名氟伐他汀钠,XU 62-320
化学名sodium;7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3,5-dihydroxyhept-6-enoate
Canonical SMILESCC(C)N1C2=CC=CC=C2C(=C1C=CC(CC(CC(=O)[O-])O)O)C3=CC=C(C=C3)F.[Na+]
分子式C24H25FNNaO4
分子量433.45
溶解度50 mg/mL in Water (Need ultrasonic); 50 mg/mL in DMSO (Need ultrasonic)
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Fluvastatin sodium is an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase [1].

Fluvastatin is a drug used to treat patients with hypercholesterolaemia. It lowers serum total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) as well as the serum apolipoprotein B. It also increases high density lipoprotein cholesterol (HDL-C) levels and apolipoprotein A-I levels. In addition to these, fluvastatin has antiatherogenic, antithrombotic and antioxidant effects. In U937 human monocyte cells, fluvastatin reduces the expression of adhesion molecules thus reducing the interaction between monocytes and endothelial cells. Fluvastatin dose-dependently reduces the platelet aggregation in vitro. The administration of fluvastatin at dose of 40 mg/day to patients reduces platelet aggregation by 10 to 15% after 4 to 24 weeks. In patients with hypercholesterolaemia, fluvastatin 40 mg/day for 8 weeks can reduce copper-induced diene production in LDL-C isolated from these patients. It is also reported that, fluvastatin can inhibit the production of NO and decreases inflammatory angiogenesis induced by the sponge matrix [1, 2].

References:
[1] Langtry HD, Markham A. Fluvastatin. A Review of its Use in Lipid Disorders. Drugs. 1999 Apr;57(4):583-606.
[2] Fernanda A. Araujo, Monaliza A. Rocha, Luciano S. A. Capettini, Paula P. Campos, Monica A. N. D. Ferreira, Virginia S. Lemos1and Silvia P. Andrade. 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (fluvastatin) decreases inflammatory angiogenesis in mice. APMIS. 2012,121:422-430.