| CAS NO: | 32981-86-5 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 5mg | 电议 |
| 25mg | 电议 |
| Cas No. | 32981-86-5 |
| 别名 | 10-脱乙酰巴卡丁 III |
| 化学名 | (2aR,4R,4aS,6S,9S,11S,12S,12aR,12bS)-12b-acetoxy-4,6,9,11-tetrahydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate |
| Canonical SMILES | O[C@](C(C)(C)C1=C(C)[C@H]2O)(C2)[C@H]([C@@H]([C@@](C([C@H]1O)=O)(C)[C@@H]3O)[C@]4([C@@H](C3)OC4)OC(C)=O)OC(C5=CC=CC=C5)=O |
| 分子式 | C29H36O10 |
| 分子量 | 544.59 |
| 溶解度 | ≥ 22.25mg/mL in DMSO, ≥ 3.96 mg/mL in EtOH with ultrasonic |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | 10-DAB (also known as 10-Deacetylbaccatin) is an intermediate used for the preparation of taxol, an anti-leukemic and tumor-inhibiting agent isolated from the inner bark of the Pacific yew treeTaxus brevifoliaas well as other species of the genusTaxus. Due to the low availability of taxol from its natural sources, 10-DAB is used as a raw material for the preparation of taxol and its derivatives. Being easily extracted from the annual cute of the yew leaves, 10-DAB has a very folded chemical structure with the α hydroxyl group hindered at C-13 easily to form a hydrogen bond with the 4α acetyl group. Reference [1].F. Gueritte-Voegelein, V. Senilh, B. David, D. Guenard and P. Potier. Chemical studies of 10-deacetyl baccatin III hemisynthesis of taxol derivatives. Tetrahedron 1986; 42(16): 4451-4460 |
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