您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > T-1105
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
T-1105
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
T-1105图片
CAS NO:55321-99-8
包装与价格:
包装价格(元)
100mg电议
200mg电议
500mg电议

产品介绍
T-1105 是一种广谱病毒聚合酶 (polymerase) 抑制剂,T-705 的结构类似物,在转化为核糖核苷三磷酸 (RTP) 代谢物后抑制 RNA 病毒的聚合酶。T-1105 (Favipiravir) 对各种 RNA 病毒表现出抗病毒活性,包括寨卡病毒 (ZIKV),流感病毒,沙粒病毒,布尼亚病毒,西尼罗病毒 (WNV),黄热病病毒 (YFV) 和口蹄疫病毒 (FMDV)。T-1105 可由烟酰胺单核苷酸腺苷酰转移酶形成。
Cas No.55321-99-8
别名3-羟基吡嗪-2-甲酰胺
Canonical SMILESO=C(C1=NC=CN=C1O)N
分子式C5H5N3O2
分子量139.11
溶解度DMSO: 25 mg/mL (179.71 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

T-1105, a novel broad-spectrum viral polymerase inhibitor, structural analogue of T-705, inhibits the polymerases of RNA viruses after being converted to ribonucleoside triphosphate (RTP) metabolite[1]. T-1105 has antiviral activity against various RNA viruses, including Zika virus (ZIKV), influenza virus, arenaviruses, bunyaviruses, West Nile virus (WNV), yellow fever virus (YFV), and foot-and-mouth disease virus (FMDV). T-1105 can be formed by nicotinamide mononucleotide adenylyltransferase[2].

[1]. Huchting J, et al. Cell line-dependent activation and antiviral activity of T-1105, the non-fluorinated analogue of T-705 (favipiravir). Antiviral Res. 2019 Jul;167:1-5. [2]. Furuta Y, et al. T-705 (favipiravir) and related compounds: Novel broad-spectrum inhibitors of RNA viral infections. Antiviral Res. 2009 Jun;82(3):95-102.