Harpagide

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Harpagide

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

6926-08-5

包装与价格：

包装	价格(元)
1mg	电议
5mg	电议
10mg	电议
20mg	电议

产品介绍

Harpagide是一种从 Scrophularia cryptophila 中分离出来的一类鸢尾糖苷，具有抗寄生虫活性，对 T.b. rhodesiense 具有良好的体外锥虫杀虫活性，IC50 为 21 μg/mL，Harpagide 对 L. donovani 的 IC50 值为 2.0 μg/mL。Harpagide 还具有重要的抗炎活性。

Cas No.	6926-08-5
别名	哈巴苷
Canonical SMILES	O[C@H]1[C@H](O)[C@@H](O)[C@]([H])(O[C@@H]2OC=C[C@]3(O)[C@@]2([H])[C@](O)(C)C[C@H]3O)O[C@@H]1CO
分子式	C₁₅H₂₄O₁₀
分子量	364.35
溶解度	Soluble in DMSO
储存条件	4°C, protect from light
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	Harpagide is a class of iridoid glycoside isolated from Scrophularia cryptophila and has antiparasitic activity, which exhibits good in vitro trypanocidal activities against African trypanosomes (T.b. rhodesiense) with an IC50 of 21 μg/mL. Harpagide exerts significant antileishmanial activity against L. donovani with an IC50 value of 2.0 μg/mL. Harpagide also possess significant anti-inflammatory activities[1][2]. Harpagide shows cytotoxic activity over 50% in a concentration of 90 μg/mL, Harpagide on the A431 and HeLa cell lines. The cytotoxic effect of Harpagide on the MCF7 cell line in a concentration of 90 μg/mL[3]. [1]. Tasdemir D, et al. Evaluation of antiprotozoal and antimycobacterial activities of the resin glycosides and the other metabolites of Scrophularia cryptophila. Phytomedicine. 2008 Mar;15(3):209-15. [2]. Zhang L, et al. Effects of β-glucosidase hydrolyzed products of harpagide and harpagoside on cyclooxygenase-2 (COX-2) in vitro. Bioorg Med Chem. 2011 Aug 15;19(16):4882-6. [3]. HÁznagy-Radnai E, et al. Cytotoxic activities of Stachys species. Fitoterapia. 2008 Dec;79(7-8):595-7.