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Cyclosporin C
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Cyclosporin C图片
CAS NO:59787-61-0
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
环孢菌素 C 是一种真菌代谢物，已在 T.
Cas No.59787-61-0
别名环孢菌素C
Canonical SMILESCC(C)C[C@@H](C(N[C@@H](C)C(N[C@H](C)C(N([C@@H](CC(C)C)C(N(C)[C@@H](CC(C)C)C1=O)=O)C)=O)=O)=O)N(C([C@H](C(C)C)NC([C@@H](N(C(CN(C([C@@]([C@H](O)C)([H])NC([C@](N(C([C@H](C(C)C)N1C)=O)C)([H])[C@H](O)[C@H](C)C/C=C/C)=O)=O)C)=O)C)CC(C)C)=O)=O)C
分子式C62H111N11O13
分子量1218.6
溶解度DMF: 20 mg/ml,DMF:PBS (pH 7.2) (1:3): 0.25 mg/ml,DMSO: 3 mg/ml,Ethanol: 14 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Cyclosporin C is a fungal metabolite that has been found in T. inflatum and has diverse biological activities, including antifungal, antiviral, and immunosuppressant properties.1,2,3,4 It is active against isolates of B. cinerea, A. niger, and Alternaria, Mucor, and Penicillium species (MICs = 0.1-5 μg/ml).2 Cyclosporin C (15 μg/ml) inhibits vaccinia virus replication in infected BSC40 cells by 98.82%.3 It inhibits lymphocyte proliferation induced by the mitogens concanavalin A , phytohemagglutinin L (PHA), and pokeweed mitogen (PWM), as well as proliferation induced by alloantigen in mixed lymphocyte culture when used at a concentration of 100 ng/ml.4 Cyclosporin C (100 ng/ml) inhibits the local graft versus host (GVH) reaction in mice receiving splenocyte grafts.

|1. von Wartburg, A., and Traber, R. Cyclosporins, fungal metabolites with immunosuppressive activities. Prog. Med. Chem. 25, 1-33 (1988).|2. Moussa•f, M., Jacques, P., Schaarw•chter, P., et al. Cyclosporin C is the main antifungal compound produced by Acremonium luzulae. Appl. Environ. Microbiol. 63(5), 1739-1743 (1997).|3. Damaso, C.R., and MoussatchÉ, N. Inhibition of vaccinia virus replication by cyclosporin A analogues correlates with their affinity for cellular cyclophilins. J. Gen. Virol. 79(Pt 2), 339-346 (1998).|4. Sadeg, N., Pham-Huy, C., Rucay, P., et al. In vitro and in vivo comparative studies on immunosuppressive properties of cyclosporines A, C, D and metabolites M1, M17 and M21. Immunopharmacol. Immunotoxicol. 15(2-3), 163-177 (1993).