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Blasticidin S HCl
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Blasticidin S HCl图片
CAS NO:3513-03-9
包装与价格：
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
Antibiotic, inhibits protein synthesis
Cas No.3513-03-9
别名灭瘟素S盐酸盐
化学名(2S,3S,6R)-3-[[(3R)-3-amino-5-[carbamimidoyl(methyl)amino]pentanoyl]amino]-6-(4-amino-2-oxopyrimidin-1-yl)-3,6-dihydro-2H-pyran-2-carboxylic acid;hydrochloride
Canonical SMILESCN(CCC(CC(=O)NC1C=CC(OC1C(=O)O)N2C=CC(=NC2=O)N)N)C(=N)N.Cl
分子式C17H27ClN8O5
分子量458.9
溶解度H2O/HAc (50:50): 10mg/mL
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Blasticidin S HCl is an antibiotic inhibiting protein synthesis [1].

Blasticidin S is isolated from Streptomyces griseochromogenes and inhibits protein synthesis in both prokaryotic and eukaryotic cells.

Blasticidin S HCl is an antibiotic inhibiting protein synthesis. In mouse leukemia L5178Y cells, blasticidin S inhibited protein synthesis and caused the degradation of presumptive mRNA [1]. Also, blasticidin S inhibited ribonuclease P activity from Dictyostelium discoideum and inhibited tRNA maturation in a dose dependent way [2]. In S. cerevisiae, blasticidin S inhibited protein synthesis induced by galactose. In Aspergillus parasiticus, blasticidin S inhibited aflatoxin production without inhibition of fungal growth. In Aspergillus flavus, blasticidin S significantly reduced aflatoxin biosynthetic enzymes [3]. Blasticidin S efficiently bound Cu2+ ions and protected DNA from metal-induced damage [4]. Blasticidin S enhanced the binding of tRNA to the P site of the large ribosomal subunit and slowed spontaneous intersubunit rotation. Blasticidin S inhibited peptide bond formation and peptidyl-tRNA hydrolysis [5].

References:
[1]. Takenaka K, Endo H, Kuwano M. The synthesis and degradation of presumptive messenger RNA in cultured mouse leukemia cells during the inhibition of protein synthesis. Biochim Biophys Acta, 1978, 521(1): 295-307.
[2]. Stathopoulos C, Tsagla A, Tekos A, et al. Effect of peptidyltransferase inhibitors on ribonuclease P activity from Dictyostelium discoideum. Effect of antibiotics on RNase P. Mol Biol Rep, 2000, 27(2): 107-111.
[3]. Yoshinari T, Noda Y, Yoda K, et al. Inhibitory activity of blasticidin A, a strong aflatoxin production inhibitor, on protein synthesis of yeast: selective inhibition of aflatoxin production by protein synthesis inhibitors. J Antibiot (Tokyo), 2010, 63(6): 309-314.
[4]. Stokowa-Soltys K, Jezowska-Bojczuk M. A rice fungicide blasticidin S efficiently binds Cu(II) ions and prevents DNA from metal-induced damage. J Inorg Biochem, 2013, 127: 73-78.
[5]. Svidritskiy E, Ling C, Ermolenko DN, et al. Blasticidin S inhibits translation by trapping deformed tRNA on the ribosome. Proc Natl Acad Sci U S A, 2013, 110(30): 12283-12288.