| CAS NO: | 136164-66-4 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| Cas No. | 136164-66-4 |
| 别名 | APX-3330 |
| 化学名 | (E)-2-((4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)methylene)undecanoic acid |
| Canonical SMILES | CCCCCCCCC/C(C(O)=O)=C([H])\C(C1=O)=C(C(C(OC)=C1OC)=O)C |
| 分子式 | C21H30O6 |
| 分子量 | 378.46 |
| 溶解度 | ≥ 75.4mg/mL in DMSO, ≥ 75.4mg/mL in EtOH |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 文献引用 | |
| 产品描述 | AP endonuclease 1 (APE1) is a dual-function protein, which contains a redox domain and a DNA repair domain. APE1 is overexpressed in numerous solid cancers, including prostate and bladder cancers, non-small cell lung cancers, gliomas, medulloblastomas and primitive neurectodermal tumors, osteosarcomas, and germ cell tumors. E3330 is a small molecule inhibitor of redox activity of APE1 protein. In vitro: E3330 significantly reduces the growth of human pancreatic cancer cells in vitro. This phenomenon was further confirmed by a small interfering RNA experiment to knockdown APE1 expression in pancreatic cancer cells. Furthermore, the growth-inhibitory effects of E3330 are accentuated by hypoxia, and this is accompanied by striking inhibition in the DNA binding ability of hypoxia-inducible factor-1α [1]. In vivo: Oral pretreatment with E3330 attenuated the elevation of plasma tumor necrosis factor activity and protected micefrom liver injury. Furthermore, E3330 inhibited the production of tumor necrosis factor from cultured Propionibacterium acnes-elicited murine peritoneal macrophages on stimulation with lipopolysaccharide in vitro [2]. Clinical trial: Up to now, E3330 is still in the preclinical development stage. Reference: |
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