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Oxolinic acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Oxolinic acid图片
CAS NO:14698-29-4
包装与价格:
包装价格(元)
100mg电议
500mg电议

产品介绍
Oxolinic acid 是一种针对革兰氏阴性和革兰氏阳性细菌的抗生素。
Cas No.14698-29-4
别名恶喹酸
化学名5-ethyl-8-oxo-5,8-dihydro-[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid
Canonical SMILESCCN1C=C(C(O)=O)C(C2=CC(OCO3)=C3C=C21)=O
分子式C13H11NO5
分子量261.23
溶解度0.5 M NaOH: 50 mg/ml
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

IC50: 4.3 μM for dopamine uptake

Oxolinic acid is a quinolone antibiotic inhibiting bacterial DNA gyrase.

DNA gyrase, an enzyme within the class of topoisomerase, relieves strain while double-stranded DNA is being unwound by helicase.

In vitro: Previous study found that both inhibitors of DNA gyrase of oxolinic acid and coumermycin A1 could block the DNA synthesis in E. coli. Moreover, the rate of bacterial DNA synthesis first rapidly declined but then increased gradually at low concentrations of oxolinic acid. In varoius DNA mutants, oxolinic acid was able to cause a rapid decline, followed by a slow decrease in synthesis rate of DNA [1].

In vivo: Animal study showed that the i.p. injection of oxolinic acid in mice could induce a dose dependent increase in locomotor activity, and such stimulation culminated at the 32 mg/kg dose and was smaller for higher doses at 64-128 mg/kg. When compared with haloperidol (D2 dopamine receptor antagonist) at increasing doses (50-100-200 mg/kg), the stimulant locomotor effect of oxolinic acid at 32 mg/kg was not reversed significantly. In addition, oxolinic acid at 32 mg/kg did not reverse the reserpine caused akinesia and even opposed the reversion that was induced by dexamphetamine [2].

Clinical trial: Oxolinic acid is an antibiotic developed in Japan in the 1970s. Oral dose at 12–20 mg/kg is administered for 5-10 days (https://en.wikipedia.org/wiki/Oxolinic_acid).

References:
[1] E C Engle,S H Manes, and K Drlica.  Differential effects of antibiotics inhibiting gyrase. J Bacteriol. 1982 Jan; 149(1): 92–98.
[2] Garcia de Mateos-Verchere J,Vaugeois JM,Naudin B,Costentin J.  Behavioural and neurochemical evidence that the antimicrobial agent oxolinic acid is a dopamine uptake inhibitor. Eur Neuropsychopharmacol. 1998 Dec;8(4):255-9.