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Trioxsalen
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Trioxsalen图片
CAS NO:3902-71-4
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Trioxsalen (Trisoralen) 是一种补骨脂素衍生物,是一种光化学 DNA 交联剂。
Cas No.3902-71-4
别名三甲沙林; Trisoralen; Trioxysalen; TMP
化学名2,5,9-trimethyl-7H-furo[3,2-g][1]benzopyran-7-one
Canonical SMILESCC1=CC2=CC(C(C)=C3)=C(C(C)=C2O1)OC3=O
分子式C14H12O3
分子量228.2
溶解度Soluble in dichloromethane
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Trioxsalen has been reported to intercalate into DNA forming DNA single-strand adducts and interstrand crosslinks when activated with UV light.

In vitro: Trioxsalen (trimethylpsoralen, trioxysalen or trisoralen) is a furanocoumarin and a psoralen derivative. It is obtained from several plants, mainly Psoralea corylifolia. Like other psoralens it causes photosensitization of the skin. After photoactivation it creates interstrand cross-links in DNA, which can cause programmed cell death unless repaired by cellular mechanisms. In research it can be conjugated to dyes for confocal microscopy and used to visualize sites of DNA damage [1].

In vivo: Mice received 3H-trioxsalen either orally or intraperitoneally. It was found that over 88% of trioxsalen, after po or i.p. administration, was excreted in the urine within 8 hours and over 90% within 12 hours. The distribution patterns of trioxsalen radioactivity demonstrated that trioxsalen was selectively present in liver, skin, and blood and was barely detectable in other organs. The highest values were observed between 2 and 6 hours and diminished rapidly thereafter [1].

Clinical trial: In men receiving 40 mg unlabelled trioxsalen, 80% of the administered dose was excreted in urine within 8 hours as hydroxylated or glucuronide derivatives. It was also reported that trioxsalen transformed to a principal metabolite 5'-carboxy-4,8-dimethylpsoralen, which was found to be inactive as skin photosensitizer and to this transformation had been attributed the difference in the photoreactivity of trioxsalen when topically applied or systematically administered [1].

Reference:
[1] Mahmoud M. A. Hassan. Trioxsalen. Analytical Profiles of Drug Substances Volume 10, 1981, Pages 705-727.