TNF-α antagonist is an exocyclic peptide that mimics the critical TNF-α recognition loop on TNF receptor I complex and, thus, prevents ligand interaction with the receptor.
| Cas No. | 199999-60-5 |
| Canonical SMILES | [H]N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CO)C(N[C@@H](CCC(N)=O)C(N[C@H](C(N[C@@H](CC(C)C)C1=O)=O)CC2=CC=C(O)C=C2)=O)=O)=O)CC3=CNC4=C3C=CC=C4)=O)CSSC[C@H](N1)C(N[C@H](C(O)=O)CC5=CC=C(O)C=C5)=O)=O)CC6=CC=C(O)C=C6 |
| 分子式 | C58H71N11O15S2 |
| 分子量 | 1226.4 |
| 溶解度 | DMSO: 5 mg/ml,DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | TNF-α antagonist is an exocyclic peptide that mimics the critical TNF-α recognition loop on TNF receptor I complex and, thus, prevents ligand interaction with the receptor. By blocking the TNF receptor ligand contact site, this peptide interferes with both activating receptor activator of NF-κB (RANK) and TNF-α's recruitment and activation of osteoclasts. TNF-α antagonist has been used to block bone resorption in the study of systemic bone loss in rheumatoid arthritis and inflammatory bone destruction. |
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