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IDO/TDO-IN-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
IDO/TDO-IN-1图片
CAS NO:2033173-01-0
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
IDO/TDO-IN-1 (compound 25) 是一种高效的、具有口服活性的吲哚胺-2,3-双加氧酶 (IDO) 和色氨酸 2,3-双加氧酶 (TDO) 双重抑制剂,IC50 值分别为 9.7 nM 和 47 nM。
Cas No.2033173-01-0
Canonical SMILESCN1N=CC(C2=CC=C(N3CCC([C@@H](C4=C5C=CC=C4F)N6C5=CN=C6)CC3)C=C2)=C1
分子式C25H24FN5
分子量413.49
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

IDO/TDO-IN-1 (compound 25) is a highly potent and orally active dual indoleamine-2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) inhibitor with IC50s of 9.7 and 47 nM, respectively [1]. IC50: 9.7 nM (Indoleamine-2,3-dioxygenase), 47 nM (Tryptophan 2,3-dioxygenase)[1]

IDO/TDO-IN-1 inhibits IDO in the Hela cell line with an IC50 of 76 nM[1].

[1]. Tu W, et al. Discovery of Imidazoisoindole Derivatives as Highly Potent and Orally Active Indoleamine-2,3-dioxygenase Inhibitors. ACS Med Chem Lett. 2019 Jun 3;10(6):949-953.