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Oteseconazole
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Oteseconazole图片
CAS NO:1340593-59-0
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Oteseconazole (VT-1161) 是一种有效、可口服的抗真菌剂，有效结合并抑制白色念球菌的 CYP51 (Kd，<39 nM)，但对人 CYP51 无明显作用。
Cas No.1340593-59-0
别名VT-1161
Canonical SMILESO[C@@](CN1C=NN=N1)(C(C=CC(F)=C2)=C2F)C(F)(C3=CC=C(C4=CC=C(OCC(F)(F)F)C=C4)C=N3)F
分子式C23H16F7N5O2
分子量527.39
溶解度DMSO: ≥ 270 mg/mL (511.96 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Oteseconazole (VT-1161) is an orally active anti-fungal agent, potently binds to and inhibits Candida albicans CYP51 (Kd,<39 nM), shows no obvious effect on human CYP51[1][2].

[1]. Warrilow AG, et al. The clinical candidate VT-1161 is a highly potent inhibitor of Candida albicans CYP51 but fails to bind the human enzyme. Antimicrob Agents Chemother. 2014 Dec;58(12):7121-7. [2]. Garvey EP, et al. VT-1161 dosed once daily or once weekly exhibits potent efficacy in treatment of dermatophytosis in a guinea pig model. Antimicrob Agents Chemother. 2015 Apr;59(4):1992-7.