| CAS NO: | 1184136-10-4 |
| 包装 | 价格(元) |
| 10mg | 电议 |
| 50mg | 电议 |
| Cas No. | 1184136-10-4 |
| 化学名 | (3-bromophenyl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone hydrochloride |
| Canonical SMILES | O=C(C1=CC=CC(Br)=C1)N2CCC(N3CCCC3)CC2.Cl |
| 分子式 | C16H21BrN2O.HCl |
| 分子量 | 373.72 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Desiccate at RT |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | UNC-926 is a methyl-lysine (Kme) reader domain inhibitor; inhibits L3MBTL1 with an IC50 of 3.9 μM. UNC-926 inhibits L3MBTL1 with an IC50 of 3.9 μM. L3MBTL1UNC-926 also exhibits a low micromolar affinity for the close homolog, L3MBTL3, with a decrease in affinity for the other MBT domains and no binding to CBX7. UNC-926 inhibits binding of the 3xMBT domain to H4K20me1. It selectively inhibits the L3MBTL13xMBT-H4K20me1 interaction in a dose-dependent manner. UNC-926 does not have an effect on the binding of 53BP1 to H4K20me1, demonstrating specificity of UNC-926 for L3MBTL1 over 53BP1[1]. References: |
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