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NFAT Inhibitor
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NFAT Inhibitor图片
CAS NO:249537-73-3
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
NFAT Inhibitor (VIVIT peptide) 是一种细胞渗透性肽抑制剂,可选择性抑制钙调神经磷酸酶介导的 NFAT 去磷酸化。
Cas No.249537-73-3
别名VIVIT peptide
化学名(S)-2-((Z)-((S)-2-((Z)-((S)-2-((Z)-(((S)-1-((1Z,3S,4Z,6S,7Z,9S,10Z,12S,13Z,15S,16Z)-1-((S)-1-((S)-2-((Z)-(((S)-1-(2-((Z)-((S)-2-((Z)-((S)-2-amino-1-hydroxy-4-(methylthio)butylidene)amino)-1-hydroxypropylidene)amino)acetyl)pyrrolidin-2-yl)(hydroxy)methylen
Canonical SMILESCC[C@]([C@@](/N=C(O)/[C@](/N=C(O)/[C@]1([H])CCCN1C([C@](/N=C(O)/[C@]2([H])CCCN2C(C/N=C(O)/[C@](/N=C(O)/[C@](N)([H])CCSC)([H])C)=O)([H])CC3=CN=CN3)=O)([H])C(C)C)([H])/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/CC(N4CCC[C@@]4([H])/C(O)=N/[C@@](/C(O)=N
分子式C75H118N20O22S
分子量1683.93
溶解度≥ 179.9 mg/mL in DMSO with ultrasonic,<8.44 mg/mL in EtOH, ≥ 34.54 mg/mL in Water with ultrasonic
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

NFAT Inhibitor (VIVIT peptide) is a cell-permeable peptide inhibitor of nuclear factor of activated Tcells (NFAT) that selectively inhibits calcineurin-mediated dephosphorylation of NFAT[1][2].

NFAT Inhibitor treatment significantly inhibits nuclear translocation of NFATc1 for 24 hours. Long-term treatment with VIVIT significantly inhibits the cytoplasmic levels of cathepsin K, TRAP, and MMP-9[2].

References:
[1]. Aramburu J, et al. Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A. Science. 1999 Sep 24;285(5436):2129-33.
[2]. Ma JD, et al. Activation of the Peroxisome Proliferator-Activated Receptor γ Coactivator 1β/NFATc1 Pathway in Circulating Osteoclast Precursors Associated With Bone Destruction in Rheumatoid Arthritis. Arthritis Rheumatol. 2019 Aug;71(8):1252-1264.